平成30年度発足 新学術領域研究
発動分子科学

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研究成果 - A01

【原著論文】      【書籍/総説・解説】

原著論文
Stereoselectivity in spontaneous assembly of rolled incommensurate carbon bilayers
T. Matsuno, Y. Ohtomo, M. Someya & H. Isobe, Nature Communications(2021), DOI: 10.1038/s41467-021-21889-8

Tight chemomechanical coupling of the F1 motor relies on structural stability
M. Tanaka, T. Kawakami, T. Okaniwa, Y. Nakayama, S. Toyabe, *H. Ueno, *E. Muneyuki, Biophys. J. (2020), in press

Structural Deformation Energy Modulation Strategy in a Soft Porous Coordination Polymer with Interpenetrated Framework
Y. Gu, J. J. Zheng, K. Otake, K. Sugimoto, N. Hosono, S. Sakaki, *F. Li, *S. Kitagawa, Angew. Chem. Int. Ed. (2020), in press, DOI: 10.1002/anie.202003186

How Cytoplasmic Dynein Couples ATP Hydrolysis Cycle to Diverse Stepping Motions: Kinetic Modeling
S. Kubo, T. Shima, *S. Takada, Biophys. J. (2020), in press, DOI: 10.1016/j.bpj.2020.03.012

Dynamic behavior of an artificial protein needle contacting a membrane observed by high-speed atomic force microscopy
*T. Ueno, K. Niwase, D. Tsubokawa, K. Kikuchi, N. Takai, T. Furuta, R. Kawano, T. Uchihashi, Nanoscale, 12, 8166-8173 (2020), DOI: 10.1039/D0NR01121E

Methodology for further thermostabilization of an intrinsically thermostable membrane protein using amino-acid mutations with its original function being retained?
S. Yasuda, T. Akiyama, S. Nemoto, T. Hayashi, T. Ueta, K. Kojima, T. Tsukamoto, S. Nagatoishi, K. Tsumoto, Y. Sudo, *M. Kinoshita, & *T. Murata, J. Chem. Inf. Model., 60, 1709-1716 (2020), DOI: 10.1021/acs.jcim.0c00063

‘Click’ conjugated porous polymer nanofilm with a large domain size created by a liquid/liquid interfacial protocol
J. Komeda, R. Shiotsuki, A. Rapakousiou, *R. Sakamoto, R. Toyoda, K. Iwase, M. Tsuji, K. Kamiya, H. Nishihara, Chem. Commun., 56, 3677-3680 (2020), DOI: 10.1039/D0CC00360C

How Does a Microbial Rhodopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained?
T. Hayashi, S. Yasuda, K. Suzuki, T. Akiyama, K. Kanehara, K. Kojima, M. Tanabe, R. Kato, T. Senda, Y. Sudo, *T. Murata, & *M. Kinoshita, J. Phys. Chem. B, 124, 990-1000 (2020), DOI: 10.1021/acs.jpcb.9b10700

Recognition of Polymer Terminus by Metal–Organic Frameworks Enabling Chromatographic Separation of Polymers
N. Mizutani, N. Hosono, B. L. Ouay, T. Kitao, R. Matsuura, T. Kubo, *T. Uemura, J. Am. Chem. Soc., 142, 3701–3705 (2020), DOI: 10.1021/jacs.9b13568

Observation of an Exotic State of Water in the Hydrophilic Nanospace of Porous Coordination Polymers
*T. Ichii, T. Arikawa, K. Omoto, N. Hosono, H. Sato, S. Kitagawa, *K. Tanaka, Commun. Chem., 3, 16 (2020), DOI: 10.1038/s42004-020-0262-9

Small stepping motion of processive dynein revealed by load-free high-speed single-particle tracking
J. Ando, T. Shima, R. Kanazawa, R. Shimo-Kon, A. Nakamura, M. Yamamoto, T. Kon and R. Iino,
Scientific Reports
, 10, 1080(2020), DOI:10.1038/s41598-020-58070-y

Rotary catalysis of bovine mitochondrial F1-ATPase studied by single-molecule experiments
R. Kobayashi, H. Ueno, C. B. Li, *H. Noji, Proc. Natl. Acad. Sci. USA., 117, 1447-1456 (2020), DOI:10.1073/pnas.1909407117

Regioselective Chemical Modification of Cysteine Residues on Protein Surfaces Focusing on Local Environment around the Conjugation Site
T. Miyale, R. Tamaki, M. Asanuma, Y. Fukada, S. Hirota, *T. Matsuo, Bioconjugate Chem., 31, 794 (2020), DOI: 10.1021/acs.bioconjchem.9b00869

Vectorial proton transport mechanism of RxR, a phylogenetically distinct and thermally stable microbial rhodopsin
K. Kojima, T. Ueta, T. Noji, K. Saito, K. Kanehara, S. Yoshizawa, H. Ishikita & *Y. Sudo, Sci. Rep., 10, 282 (2020), DOI:10.1038/s41598-019-57122-2

Visualizing dynamic actin cross-linking processes driven by the actin-binding protein anillin
K. Matsuda, M. Sugawa, M. Yamagishi, *N. Kodera, *J. Yajima, FEBS Letters, 594, 1237-1247, DOI: 10.1002/1873-3468.13720

Porphyrin-Based Probe for Simultaneous Detection of Interface Acidity and Polarity during Lipid-Phase Transition of Vesicles
R. Majumder, S. Roy, K. Okamoto, S. Nagao, *T. Matsuo, *P. P. Parui, Langmuir, 36, 426 (2020), DOI: 10.1021/acs.langmuir.9b02781

Regulated single‐axis rotations of a carbonaceous guest in a van der Waals complex with an entropy cost
T. Matsuno, Y. Nakai, Y. Maniwa, M. Someya, S. Sato, *H. Isobe, Chemistry An Asian Journal, 15, 273-278 (2020), DOI: 10.1002/asia.201901638

Pseudo Gated Adsorption with Negligible Volume Change Evoked by Halogen Bond Interaction in the Nanospace of MOFs
P. Kanoo, R.Matsuda,*H. Sato, L. Li, N. Hosono, S. Kitagawa, Chem. Eur. J., 26, 2148–2153 (2020), DOI: 10.1002/chem.201904703

Application of High-Sensitivity UV photoemission Spectroscopy to Examine the Electronic Structure of Thermophilic Rhodopsin
D. Sano, I. Ide, T. Akiyama, Y. Tanaka, Y. Sudo, T. Murata & H. Ishii, Mol. Crys. Liq. Crys., 687, 34-39 (2019), DOI: 10.1080/15421406.2019.1648052

A distinct lineage of giant viruses brings a rhodopsin photosystem to unicellular marine predators
D. M. Needham, S. Yoshizawa, T. Hosaka, C. Poirier, C. J. Choi, E. Hehenberger, N. A. T. Irwin, S. Wilken, C. M. Yung, C. Bachy, R. Kurihara, Y. Nakajima, K. Kojima, T. Kimura-Someya, G. Leonard, R. R. Malmstrom, D. R. Mende, D. K. Olson, Y. Sudo, S. Sude, T. A. Richard, E. F. DeLong, P. J. Keeling, A. E. Santoro, M. Shirouzu, *W. Iwasaki, & *A. Z. Worden, Proc. Natl. Acad. Sci. USA, 116, 20574-20583 (2019), DOI: 10.1073/pnas.1907517116

Tri‐ and Tetranuclear Metal‐String Complexes with Metallophilic d10–d10 Interactions
M. Olaru, J. F. Kögel, R. Aoki, R. Sakamoto, H. Nishihara, E. Lork, *S. Mebs, *M. Vogt, *J. Beckmann, Eur. J. Inorg. Chem., 26, 275-284 (2020), DOI: 10.1002/chem.201904106

Application of DNA Quadruplex Hydrogels Prepared from Polyethylene Glycol-Oligodeoxynucleotide Conjugates to Cell Culture Media
S. Tanaka, S. Yukami, Y. Hachiro, *Y. Ohya, *A. Kuzuya, Polymers, 11, 1607 (2019), DOI: 10.3390/polym11101607

Carbon Dioxide Capture and Efficient Fixation in a Dynamic Porous Coordination Polymer
Pengyan Wu, Y. Li, J. J. Zheng, N. Hosono, J. Wang, * K. Otake, Y. Liu, L. Xia, M. Jiang, S. Sakaki, *S. Kitagawa, Nat. Commun. , 10, 4362 (2019), DOI:10.1038/s41467-019-12414-z

Single-molecule analysis reveals rotational substeps and chemo-mechanical coupling scheme of
Enterococcus hirae V1-ATPase

T. Iida, Y. Minagawa, H. Ueno, F. Kawai, T. Murata and *R. Iino,
J. Biol. Chem. (2019), DOI:10.1074/jbc.RA119.008947

Accurate high-throughput screening based on digital protein synthesis in a massively parallel femtoliter droplet array
*Y. Zhang, Y. Minagawa, H. Kizoe, K. Miyazaki, R. Iino, H. Ueno, K. Tabata, Y. Shimane, *H. Noji, Sci. Adv., 5, eaav8185 (2019), DOI: 10.1126/sciadv.aav8185

Electrophysiological Analysis of Antimicrobial Peptides in Diverse Species
N. Saigo, K. Izumi, *R. Kawano, ACS Omega, 4, 13124-13130 (2019), DOI:10.1021/acsomega.9b01033

Mobile imaging platform for digital influenza virus counting
Y. Minagawa, Y. Minagawa#, H. Ueno#, K. V. Tabata, *H. Noji (#equally contributed), Lab Chip , 19, 2678-2687 (2019), DOI:10.1039/C9LC00370C

Retarded solid‐state rotations of an oval‐shaped guest in a deformed cylinder with CH–π arrays
T. Matsuno, K. Fukunaga, S. Sato, *H. Isobe, Angew. Chem. Int. Ed. , 58 , 12170-12174 (2019), DOI: 10.1002/anie.201907040

Photochemical Characterization of a New Heliorhodopsin from the Gram-Negative Eubacterium Bellilinea caldifistulae (BcHeR) and Comparison with Heliorhodopsin-48C12
A. Shibukawa, K. Kojima, Y. Nakajima, Y. Nishimura, S. Yoshizawa, *Y. Sudo, Biochemistry , 58, 2934-2943(2019) , DOI:10.7554/eLife.44928.

Electrochromic triphenylamine-based cobalt(II) complex nanosheets
Y. Liu, R. Sakamoto, *C. L. Ho, *H. Nishihara, *W.Y. Wong, J. Mater. Chem. C , 7, 9159-9166 (2019), DOI: 10.1039/c9tc02257k

GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice
S. Chowdhury, T. Matsubara, T. Miyazaki, D. Ono, N. Fukatsu, M. Abe, K. Sakimura, Y. Sudo, *A. Yamanaka, Elife , 8, e44928 (2019), DOI:10.7554/eLife.44928.

Quantitation of the neural silencing activity of anion channelrhodopsins in Caenorhabditis elegans and their applicability for long-term illumination
T. Yamanashi, M. Maki, K. Kojima, A. Shibukawa, T. Tsukamoto, S. Chowdhury, A. Yamanaka, S. Takagi, *Y. Sudo, Sci Rep., 9, 7863 (2019), DOI:110.1038/s41598-019-44308-x.

Microwave‐Assisted Hydrothermal Synthesis of [Al (OH)(1,4‐NDC)] Membranes with Superior Separation Performances
*Yi Liu, Akihiro Hori, Shinpei Kusaka, N. Hosono, M. Li, A. Guo, D. Du, Y. Li, W. Yang, Y. Ma, *R. Matsuda, Chem. Asian J., 14, 2072–2076 (2019), DOI: 10.1002/asia.201900152

Artificial Smooth Muscle Model Composed of Hierarchically Ordered Microtubule Asters Mediated by DNA Origami Nanostructures
K. Matsuda, A. M. R. Kabir, N. Akamatsu, A. Saito, S. Ishikawa, Tsuyoshi Matsuyama, O. Ditzer, M. S. Islam, Y. Ohya, K. Sada, A. Konagaya, *A. Kuzuya, *A. Kakugo, Nano Letters, 19, 3933-3938 (2019), DOI: 10.1021/acs.nanolett.9b01201

Interfacial transmetallation synthesis of a platinadithiolene nanosheet as a potential 2D topological insulator
T. Pal, S. Doi, H. Maeda, K. Wada, C. M. Tan, N. Fukui, R. Sakamoto, S. Tsuneyuki, S. Sasaki, *H. Nishihara, Chemical Science , 10, 5218-5225 (2019), DOI: 10.1039/C9SC01144G

書籍/総説・解説
The Unlimited Potential of Microbial Rhodopsins as Optical Tools
K. Kojima, A. Shibukawa, & *Y. Sudo, Biochemistry, 59, 218-229 (2020), DOI: 10.1021/acs.biochem.9b00768

Recent developments on creation of artificial metalloenzyme
*T. Matsuo, T. Miyake, S. Hirota, Tetrahedron Lett. (digest paper), 60, 151226 (2019), DOI: 10.1016/j.tetlet.2019.151226

The Accelerating World of Graphdiynes
*R. Sakamoto, N. Fukui, H. Maeda, R. Matsuoka, R. Toyoda, *H. Nishihara, Advanced Materials , 31, 1804211 (2019), DOI: 10.1002/adma.201804211
(Selected as Inside Front Cover)

・「高分子重合により合成可能な2次元カーボン:グラフィジイン」, 坂本良太・西原 寛, 高分子, 68, 303-304 (2019)

・「分子性ナノシートの新展開」, 坂本良太・西原 寛, 化学と工業, 72, 344-346 (2019)

・「ポストグラフェン材料の創製と用途開発最前線」, 柚原 淳司 (Ed.)
“ジピリンナノシートによる高効率太陽電池セルの開発”, 坂本良太、米田丈, 448, エヌ・ティー・エス, (2020), ISBN: 978-4-8604-3657-5

・「Hybrid Metal-Organic Framework and Covalent Organic Framework Polymers」, Bo Wang (Ed.)
“Polymers in Metal-Organic Frameworks: Synthesis, Recognition, and Hybrid Materials”, B. L. Ouay, T. Kitao, N. Hosono, T. Uemura, RSC, (2020), ISBN: 978-183-91-6153-7

・「Make Life Visible」, Y. Toyama, A. Miyawaki, M. Nakamura, M. Jinzaki (Eds).
“Molecular dynamics revealed by single-molecule FRET measurement”, T. Shima, *S. Uemura, Springer Nature Publishing, , 37-65 (2019), ISBN: 978-981-48-0001-3

・「グラフェンから広がる二次元物質の新技術と応用」, 吾郷浩樹, 齋藤理一郎, “分子性ナノシートの精密合成およびその物性評価”, 坂本良太, 米田 丈, 479, エヌ・ティー・エス, (2019), ISBN: 978-4-8604-3663-6

・「Handbook of Dynein (Second Edition)」, Keiko Hirose (Ed.),
"Structural and Functional Analysis of Dynein Motor Domain"
Tomohiro Shima* and Takahide Kon, Jenny Stanford Publishing, (2019) 37-65, ISBN: 9789814800013

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