平成30年度発足 新学術領域研究
発動分子科学

News&Event

研究成果 - A01-2

【原著論文】      【書籍/総説・解説】

原著論文
Robust folding of a de novo designed ideal protein even with most of the core mutated to valine
R. Koga, M. Yamamoto, T. Kosugi, N. Kobayashi, T. Sugiki, T. Fujiwara, N. Koga, PNAS , 117, 31149-31156 (2020), DOI: 10.1073/pnas.2002120117

Collective motility of dynein linear arrays built on DNA nanotubes
R. Ibusuki, M. Shiraga, A. Furuta, M. Yoshio, H. Kojima, K. Oiwa, *K. Furuta, Biochem. Biophys. Res. Commun., 523, 1014-1019 (2020), DOI: 10.1016/j.bbrc.2019.12.125

Gliding filament system giving both global orientational order and clusters in collective motion
S. Tanida, K. Furuta, K. Nishikawa, *T. Hiraiwa, H. Kojima, K. Oiwa, *M. Sano, Phys. Rev. E, 101, 032607 (2020), DOI: 10.1103/PhysRevE.101.032607

Different motilities of microtubules driven by kinesin-1 and kinesin-14 motors patterned on nano-pillars
T. Kaneko, K. Furuta, K. Oiwa, H. Shintaku, H. Kotera, *R. Yokokawa, Sci. Adv., 6, eaax7413 (2020), DOI: 10.1126/sciadv.aax7413

ShadowR: a novel chromoprotein with reduced non-specific binding and improved expression in living cells
*H. Murakoshi, H. Horiuchi, T. Kosugi, M. Onda, A. Sato, N. Koga, J. Nabekura, Sci. Rep., 9, 12072 (2019), DOI: 10.1038/s41598-019-48604-4

Kinesin-6 Klp9 plays motor-dependent and -independent roles in collaboration with Kinesin-5 Cut7 and the microtubule crosslinker Ase1 in fission yeast
*M. Yukawa, M. Okazaki, Y. Teratani, K. Furuta, *T. Toda, Sci. Rep., 9, 7336 (2019), DOI: 10.1038/s41598-019-43774-7

Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein
S. Basak, R. Paul Nobrega, D. Tavella, L.M. Deveau, N. Koga, R. Tatsumi-Koga, D. Baker, F. Massi,*C. R. Matthews, Proc. Natl. Acad. Sci. USA, 116, 6806-6811 (2019), DOI: 10.1073/pnas.1818744116

Transport of microtubules according to the number and spacing of kinesin motors on gold nano-pillars
T. Kaneko, S. Ando, K. Furuta, K. Oiwa, H. Shintaku, H. Kotera, Nanoscale, 11, 9879-9887 (2019), DOI: 10.1039/C9NR01324E

Plasmid-Based One-Pot Saturation Mutagenesis and Robot-Based Automated Screening for Protein Engineering
F.Kawai, A.Nakamura, A.Visootsat, *R.Iino, ACS Omega , 3, 7715-7726 (2018), DOI: 10.1021/acsomega.8b00663

De novo design of allosteric control into rotary motor V1-ATPase by restoring lost function
T. Kosugi, T. Iida, M. Tanabe, R. Iino, N. Koga, bioRxiv , (2020), DOI: 10.1101/2020.09.09.288571

書籍/総説・解説
整合性原理に基づくタンパク質デザイン
古賀理恵, 古賀信康, 生物物理 , 60, 325-330 (2020), DOI: 10.2142/biophys.60.325

Synthetic biology approaches to dissecting linear motor protein function: towards the design and synthesis of artificial autonomous protein walkers
H. Linke, B. Höcker, K. Furuta, N. R. Forde, *P. M. G. Curmi, Biophys Rev., 12, 1041–1054 (2020), DOI: 10.1007/s12551-020-00717-1

Consistency principle for protein design
R. Koga, *N. Koga, Biophys. & Physicobiol., 16, 304-309 (2019), DOI: 10.2142/biophysico.16.0_304

Visualization of Functional Structure and Kinetic Dynamics of Cellulases
*A.Nakamura, R.Iino, Adv. Exp. Med. Biol., 1104, 201-217 (2018), DOI: 10.1007/978-981-13-2158-0_10

・「実験医学 2019年11月号 再定義されるタンパク質の常識」,
“合理デザインによる新規タンパク質の創出:現状とその可能性”, 小杉貴洋・古賀理恵・古賀信康, 3089-3095, 羊土社 , (2019), ISBN: 978-4-7581-2525-3

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